Jakarta, goldensamoyed Indonesia
–
For the first time scientists
China
do
transplant
pig lungs to humans.Experiments were carried out to see how the immune system of the host responded to the procedure.The results were seen in 24 hours of experimentation.
Scientists involve male patients aged 39 years who are declared to be in brain death.Published in the journal Nature Medicine, scientists for the first time practicing xenotransplantation of the lungs, namely the transplant procedure from other species to humans.
“Xenotransplantation of the lungs presents unique biological and technical challenges compared to other organs,” said Jiang Shi, the author of study and doctor at the Organ Department at the First Affiliate Hospital of Guangzhou Medical University, quoting from
Live Science
.
Experiments using the lungs from a genetically modified pig.As many as three genes of pork are deactivated so that they will not activate human immunity.
Then three human genes are added so that these organs can be tolerated the human body.
In May 2024, the team lifted the left lung of the pig and transplanted it to the patient, while his right lung remained.
The body ‘refused’
After that, the patient’s body does not show the signs of “hyperacut rejection”.Although it has passed this period, the sign of rejection began to appear about 24 hours marked by swelling and inflammation.
The immune system produces antibodies against pig lungs, resulting in some damage.
However, pig lungs can “maintain viability and functionality” for 9 days even though there are signs of rejection within the first 24 hours after the procedure.
On the 9th day the experiment ended at the request of the patient’s family.From the report, it is not clear how long the organ survives if it is continued.But the organs are said to have been damaged on the 9th day.
Researchers also suggest for similar experiments in the future, first need to block the action of specific immune cells.Then it also needs to press certain signal molecules that trigger inflammation.
“Future studies can perfect the Xenotransplantation of the lungs and move closer to the clinical application,” the researcher concluded.
(rir)
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